Katepsin K

Iz Wikipedije, slobodne enciklopedije
Jump to navigation Jump to search
Katepsin K
Cathepsin K 1TU6.png
Identifikatori
EC broj 3.4.22.38
CAS broj 94716-09-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Katepsin K (EC 3.4.22.38, katepsin O2) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Široka proteolitička aktivnost na malim molekulima. Glavna odrednica specifičnosti je P2, koji je preferentno Leu, Met > Phe, i odsustvo Arg

Ovaj enzim je prominentno izražen u osteoklastima sisara.

Reference[uredi - уреди | uredi izvor]

  1. Inaoka, T., Bilbe, G., Ishibashi, O., Tezuka, K., Kumegawa, M. and Kokubo, T. (1995). "Molecular cloning of human cDNA for cathepsin K: Novel cysteine proteinase predominantly expressed in bone". Biochem. Biophys. Res. Commun. 206: 89–96. PMID 7818555. 
  2. Bossard, M.J., Tomaszek, T.A., Thompson, S.K., Amegadzie, B.Y., Hanning, C.R., Jones, C., Kurdyla, J.T., McNulty, D.E., Drake, F.H., Gowen, M. and Levy, M.A. (1996). "Proteolytic activity of human osteoclast cathepsin K - Expression, purification, activation, and substrate identification". J. Biol. Chem. 271: 12517–12524. PMID 8647860. 
  3. Bromme, D., Klaus, J.L., Okamoto, K., Rasnick, D. and Palmer, J.T. (1996). "Peptidyl vinyl sulphones: A new class of potent and selective cysteine protease inhibitors - S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L". Biochem. J. 315: 85–89. PMID 8670136. 
  4. Zhao, B.G., Janson, C.A., Amegadzie, B.Y., D'Alessio, K., Griffin, C., Hanning, C.R., Jones, C., Kurdyla, J., McQueney, M., Qiu, X.Y., Smith, W.W. and Abdel-Meguid, S.S. (1997). "Crystal structure of human osteoclast cathepsin K complex with E-64". Nature Struct. Biol. 4: 109–111. PMID 9033588. 
  5. McGrath, M.E., Klaus, J.L., Barnes, M.G. and Brömme, D. (1997). "Crystal structure of human cathepsin K complexed with a potent inhibitor". Nature Struct. Biol. 4: 105–109. PMID 9033587. 

Literatura[uredi - уреди | uredi izvor]

Spoljašnje veze[uredi - уреди | uredi izvor]