Elongacioni faktor 2 kinaza

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Elongacioni faktor 2 kinaza
Identifikatori
EC broj 2.7.11.20
CAS broj 116283-83-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Elongacioni faktor 2 kinaza (EC 2.7.11.20, Ca/CaM-kinaza III, kalmodulin-zavisni protein kinaza III, CaM kinaza III, eEF2 kinaza, eEF2K, EF2K, STK19) je enzim sa sistematskim imenom ATP:(elongacioni faktor 2) fosfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [elongacioni faktor 2] \rightleftharpoons ADP + [elongacioni faktor 2] fosfat

Za rad ovog enzima je neophodan jon Ca2+ i kalmodulin.

Reference[uredi - уреди]

  1. Mitsui, K., Brady, M., Palfrey, H.C. and Nairn, A.C. (1993). "Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas". J. Biol. Chem. 268: 13422-13433. PMID 8514778. 
  2. Hincke, M.T. and Nairn, A.C. (1992). "Phosphorylation of elongation factor 2 during Ca2+-mediated secretion from rat parotid acini". Biochem. J. 282: 877-882. PMID 1372803. 
  3. Knebel, A., Morrice, N. and Cohen, P. (2001). "A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta". EMBO J. 20: 4360-4369. PMID 11500363. 
  4. Sans, M.D., Xie, Q. and Williams, J.A. (2004). "Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini". Biochem. Biophys. Res. Commun. 319: 144-151. PMID 15158453. 
  5. Browne, G.J., Finn, S.G. and Proud, C.G. (2004). "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398". J. Biol. Chem. 279: 12220-12231. PMID 14709557. 
  6. Ryazanov, A.G. (2002). "Elongation factor-2 kinase and its newly discovered relatives". FEBS Lett. 514: 26-29. PMID 11904175. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]