Lipopolisaharid 3-a-galaktoziltransferaza
| Lipopolisaharid 3-a-galaktoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.44 | ||||||||
| CAS broj | 9073-98-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Lipopolisaharid 3-a-galaktoziltransferaza (EC 2.4.1.44, UDP-galaktoza:lipopolisaharid alfa,3-galaktoziltransferaza, UDP-galaktoza:polisaharid galaktoziltransferaza, uridin difosfat galaktoza:lipopolisaharid alfa-3-galaktoziltransferaza, uridin difosfogalaktoza-lipopolisaharid alfa,3-galaktoziltransferaza, UDP-galaktoza:lipopolisaharid 3-alfa-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:lipopolisaharid 3-alfa-D-galaktoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-galaktoza + lipopolisaharid UDP + 3-alfa-D-galaktozil-[lipopolisaharid glukoza]
Ovaj enzim prenosi alfa-D-galaktozil ostatake na D-glukozu u parcijalno završenoj srži lipopolisaharida [cf. EC 2.4.1.56 (lipopolisaharid N-acetilglukozaminultransferaza), EC 2.4.1.58 (lipopolisaharid glukoziltransferaza I) i EC 2.4.1.73 (lipopolisaharid glukoziltransferaza II)].
Reference[uredi | uredi kod]
- ↑ Endo, A. and Rothfield, L. (1969). „Studies of a phospholipid-requiring bacterial enzyme. I. Purification and properties of uridine diphosphate galactose: lipopolysaccharide α-3-galactosyl transferase”. Biochemistry 8: 3500-3507. PMID 4898284.
- ↑ Wollin, R., Creeger, E.S., Rothfield, L.I., Stocker, B.A.D. and Lindberg, A.A. (1983). „Salmonella typhimurium mutants defective in UDP-D-galactose:lipopolysaccharide α-1,6-D-galactosyltransferase. Structural, immunochemical, and enzymologic studies of rfaB mutants”. J. Biol. Chem. 258: 3769-3774. PMID 6403519.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.