Masna-kiselina sintaza
| Masna-kiselina sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.85 | ||||||||
| CAS broj | 9045-77-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Masna-kiselina sintaza (EC 2.3.1.85, kvašćana masno kiselinska sintaza) je enzim sa sistematskim imenom acil-KoA:malonil-KoA C-aciltransferaza (dekarboksilacija, oksoacil- i enoil-redukcija i tioestarska hidrolizacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- acetil-KoA + n malonil-KoA + 2n NADPH + 2n H+ dugolančana masna kiselina + (n+1) KoA + n CO2 + 2n NADP+
Životinjski enzim je multi-functionalni protein koji katalizuje reakcije EC 2.3.1.38 [acil-nosilac-protein] S-acetiltransferaza, EC 2.3.1.39 [acil-nosilac-protein] S-maloniltransferaza, EC 2.3.1.41 3-oksoacil-[acil-nosilac-protein] sintaza, EC 1.1.1.100 3-oksoacil-[acil-nosilac-protein] reduktaza, EC 4.2.1.59 3-hidroksipalmitoil-[acil-nosilac-protein] dehidrataza, EC 1.3.1.10 enoil-[acil-nosilac-protein] reduktaza (NADPH, B-specifična) i EC 3.1.2.14 oleoil-[acil-nosilac-protein] hidrolaza.
Reference[uredi | uredi kod]
- ↑ Stoops, J.K., Ross, P., Arslanian, M.J., Aune, K.C., Wakil, S.J. and Oliver, R.M. (1979). „Physicochemical studies of the rat liver and adipose fatty acid synthetases”. J. Biol. Chem. 254: 7418-7426. PMID 457689.
- ↑ Wakil, S.J., Stoops, J.K. and Joshi, V.C. (1983). „Fatty acid synthesis and its regulation”. Annu. Rev. Biochem. 52: 537-579. PMID 6137188.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.