3-Hidroksioktanoil-(acil-nosilac-protein) dehidrataza
| 3-Hidroksioktanoil-(acil-nosilac-protein) dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.59 | ||||||||
| CAS broj | 9030-85-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3-Hidroksioktanoil-(acil-nosilac-protein) dehidrataza (EC 4.2.1.59, fabZ (gen), fabA (gen), D-3-hidroksioktanoil-(acil nosilac protein) dehidrataza, D-3-hidroksioktanoil-acil nosilac protein dehidrataza, beta-hidroksioktanoil-acil nosilac protein dehidraza, beta-hidroksioktanoil tioestar dehidrataza, beta-hidroksioktanoil-ACP-dehidraza, (3R)-3-hidroksioktanoil-(acil-nosilac-protein) hidrolijaza, (3R)-3-hidroksioktanoil-(acil-nosilac-protein) hidrolijaza (formira okt-2-enoil-(acil-nosilac protein))) je enzim sa sistematskim imenom (3R)-3-hidroksioktanoil-(acil-nosilac protein) hidrolijaza (formira okt-2-enoil-(acil-nosilac protein)).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (3R)-3-hidroksiacil-[acil-nosilac protein] trans-2-enoil-[acil-nosilac protein] + H2O
Ovaje enzim je odgovoran za dehidracioni korak masna-kiselinska biosinteze biljki i bakterija.
Reference[uredi | uredi kod]
- ↑ Mizugaki, M., Swindell, A.C. and Wkil, S.J. (1968). „Intermediate- and long-chain β-hydroxyacyl-ACP dehydrases from E. coli fatty acid synthetase”. Biochem. Biophys. Res. Commun. 33: 520-527. PMID 4881058.
- ↑ Sharma, A., Henderson, B.S., Schwab, J.M. and Smith, J.L. (1990). „Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli”. J. Biol. Chem. 265: 5110-5112. PMID 2180957.
- ↑ Mohan, S., Kelly, T.M., Eveland, S.S., Raetz, C.R. and Anderson, M.S. (1994). „An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis”. J. Biol. Chem. 269: 32896-32903. PMID 7806516.
- ↑ Heath, R.J. and Rock, C.O. (1996). „Roles of the FabA and FabZ β-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis”. J. Biol. Chem. 271: 27795-27801. PMID 8910376.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.