Protein-S-izoprenilcistein O-metiltransferaza
| Protein-S-izoprenilcistein O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.100 | ||||||||
| CAS broj | 130731-20-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Protein-S-izoprenilcistein O-metiltransferaza (EC 2.1.1.100, farnezil cistein C-terminalna metiltransferaza, farnezil-proteinska karboksimetiltransferaza, protein C-terminal farnezilcisteinska O-metiltransferaza, farnezilated protein C-terminalna O-metiltransferaza, izoprenilaciona proteinska metiltransferaza, prenilaciona proteinska metiltransferaza, protein S-farnezilcistein C-terminalna metiltransferaza, S-farnezilcisteinska metiltransferaza, prenilcisteinska karboksilmetiltransferaza, prenilcisteinska karboksimetiltransferaza, prenilcisteinska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:protein-C-terminal-S-farnezil-L-cistein O-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + protein C-terminalni S-farnezil-L-cistein S-adenozil-L-homocistein + protein C-terminalni S-farnezil-L-cistein metil estar
C-terminalni S-geranilgeranilcistein i S-geranilcistein ostaci se takođe metilišu, mada sporije.
Reference[uredi | uredi kod]
- ↑ Clarke, S., Vogel, J.P., Deschenes, R.J. and Stock, J. (1988). „Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases”. Proc. Natl. Acad. Sci. USA 85: 4643-4647. PMID 3290900.
- ↑ Ota, I.M. and Clarke, S. (1989). „Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues”. J. Biol. Chem. 264: 12879-12884. PMID 2753892.
- ↑ Stephenson, R.C. and Clarke, S. (1990). „Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate”. J. Biol. Chem. 265: 16248-16254. PMID 2398053.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.