KoA-glutation reduktaza
(Preusmjereno sa stranice EC 1.8.1.10)
| KoA-glutation reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.1.10 | ||||||||
| CAS broj | 37256-33-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
KoA-glutation reduktaza (EC 1.8.1.10, koenzim A glutation disulfidna reduktaza, NADPH-zavisna koenzim A-SS-glutationska reduktaza, koenzim A disulfid-glutationska reduktaza, NADPH:KoA-glutationska oksidoreduktaza) je enzim sa sistematskim imenom glutation:NADP+ oksidoreduktaza (KoA-acilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- KoA + glutation + NADP+ KoA-glutation + NADPH + H+
Ovaj enzim je flavoprotein. Supstrat je mešoviti disulfid.
Reference[uredi | uredi kod]
- ↑ Ondarza, R.N., Abney, R. and López-Colomé, A.M. (1969). „Characterization of a NADPH-dependent coenzyme A-SS-glutathione reductase from yeast”. Biochim. Biophys. Acta 191: 239-248. PMID 4390951.
- ↑ Ondarza, R.N., Escamilla, E., Gutierrez, J. and De la Chica, G. (1974). „CoAS-Sglutathione and GSSG reductases from rat liver. Two disulfide oxidoreductase activities in one protein entity”. Biochim. Biophys. Acta 341: 162-171. PMID 4151341.
- ↑ Carlberg, I. and Mannervik, B. (1977). „Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione”. Biochim. Biophys. Acta 484: 268-274. PMID 334266.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.