Digalaktozildiacilglicerol sintaza
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| Digalaktozildiacilglicerol sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.241 | ||||||||
| CAS broj | 69913-00-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Digalaktozildiacilglicerol sintaza (EC 2.4.1.241, DGD1, DGD2, DGDG sintaza, UDP-galaktoza-zavisna DGDG sintaza, UDP-galaktoza-zavisna digalaktozildiacilglicerol sintaza, UDP-galaktoza:MGDG galaktoziltransferaza, UDP-galaktoza:3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol 6-alfa-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol 6-alfa-galaktoziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-galaktoza + 3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol UDP + 3-[alfa-D-galaktozil-(1->6)-beta-D-galaktozil]-1,2-diacil-sn-glicerol
Za dejstvo ovog enzima je neophodan Mg2+. Diacilglicerol ne može da služi kao akceptorski molekule za galaktozilaciju u reakciji katalizovanoj enzimom EC 2.4.1.46, monogalaktozildiacilglicerol sintaza.
Reference[uredi | uredi kod]
- ↑ Kelly, A.A. and Dörmann, P. (2002). „DGD2, an Arabidopsis gene encoding a UDP-galactose-dependent digalactosyldiacylglycerol synthase is expressed during growth under phosphate-limiting conditions”. J. Biol. Chem. 277: 1166-1173. PMID 11696551.
- ↑ Härtel, H., Dörmann, P. and Benning, C. (2000). „DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in Arabidopsis”. Proc. Natl. Acad. Sci. USA 97: 10649-10654. PMID 10973486.
- ↑ Kelly, A.A., Froehlich, J.E. and Dörmann, P. (2003). „Disruption of the two digalactosyldiacylglycerol synthase genes DGD1 and DGD2 in Arabidopsis reveals the existence of an additional enzyme of galactolipid synthesis”. Plant Cell 15: 2694-2706. PMID 14600212.
- ↑ Benning, C. and Ohta, H. (2005). „Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants”. J. Biol. Chem. 280: 2397-2400. PMID 15590685.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.