Diftin sintaza
| Diftin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.98 | ||||||||
| CAS broj | 114514-25-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Diftin sintaza (EC 2.1.1.98, S-adenozil-L-metionin:elongacioni faktor 2 metiltransferaza, diftinska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:2-(3-karboksi-3-aminopropil)-L-histidin metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + 2-(3-karboksi-3-aminopropil)-L-histidin S-adenozil-L-homocistein + 2-[3-karboksi-3-(metilamonio)propil]-L-histidin
2-[3-karboksi-3-(metilamonijum)propil]-L-histidin i korespondirajuća dimetil jedinjenja mogu takođe da deluju kao akceptori.
- ↑ Chen, J.-Y.C. and Bodley, J.W. (1988). „Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase”. J. Biol. Chem. 263: 11692-11696. PMID 3042777.
- ↑ Moehring, J.M. and Moehring, T.J. (1988). „The post-translational trimethylation of diphthamide studied in vitro”. J. Biol. Chem. 263: 3840-3844. PMID 3346227.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.