Defosfo-(reduktaza kinaza) kinaza

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Defosfo-(reduktaza kinaza) kinaza
Identifikatori
EC broj 2.7.11.3
CAS broj 72060-33-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3, AMP-activirana kinaza, AMP-activirana proteinska kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza, hidroksimetilglutaril koenzim A reduktaza kinaza kinaza (fosforilacija), reduktazna kinaza, reduktazna kinaza kinaza, STK30) je enzim sa sistematskim imenom ATP:defosfo(hidroksimetilglutaril-KoA reduktaza (NADPH)) kinaza} fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + defosfo[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza} ADP + {[hidroksimetilglutaril-KoA reduktaza (NADPH)] kinaza}

Ovaj enzim se aktivira AMP-om i specifičan je za svoj supstrat.

Reference[uredi - уреди | uredi izvor]

  1. Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1979). "Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase". Proc. Natl. Acad. Sci. USA 76: 4375–4379. PMID 291971. 
  2. Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M. (1978). "Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation". Biochem. Biophys. Res. Commun. 81: 1268–1277. PMID 666819. 
  3. Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1985). "Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase". J. Biol. Chem. 260: 1682–1687. PMID 3155737. 
  4. Clarke, P.R. and Hardie, D.G. (1990). "Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver". EMBO J. 9: 2439–2446. PMID 2369897. 
  5. Sato, R., Goldstein, J.L. and Brown, M.S. (1993). "Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion". Proc. Natl. Acad. Sci. USA 90: 9261–9265. PMID 8415689. 

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