Decilhomocitrat sintaza
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| Decilhomocitrat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.3.4 | ||||||||
| CAS broj | 51845-40-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Decilhomocitrat sintaza (EC 2.3.3.4, 2-decilhomocitratna sintaza, 3-hidroksitetradekan-1,3,4-trikarboksilat 2-oksoglutaratna lijaza (KoA-acilacija)) je enzim sa sistematskim imenom dodekanoil-KoA:2-oksoglutarat C-dodekanoiltransferaza (tioestarska hidroliza, formiranje 1-karboksiundecila).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dodekanoil-KoA + H2O + 2-oksoglutarat (3S,4S)-3-hidroksitetradekan-1,3,4-trikarboksilat + KoA
Dekanoil-KoA može da deluje umesto dodekanoil-KoA.
Reference[uredi | uredi kod]
- ↑ Maahlén, A. (1973). „Purification and some properties of 2-decylhomocitrate synthase from Penicillium spiculisporum”. Eur. J. Biochem. 38: 32-39. PMID 4774124.
- ↑ Brandäge, S., Dahlman, O., Lindqvist, B., Maahlén, A. and Mörch, L. (1984). „Absolute configuration and enantiospecific synthesis of spiculisporic acid”. Acta Chem. Scand. 38B: 837-844.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.