DNK-3-metiladeninska glikozilaza II
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| DNK-3-metiladeninska glikozilaza II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.2.21 | ||||||||
| CAS broj | 89287-38-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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DNK-3-metiladeninska glikozilaza II (EC 3.2.2.21, dezoksiribonukleatna 3-metiladeninska glikozidaza II, 3-metiladeninska DNK glikozilaza II, DNK-3-metiladeninska glikozidaza II, AlkA) je enzim sa sistematskim imenom glikohidrolaza alkilisane DNK (otpuštanje metiladenina i metilguanina).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza alkilisane DNK uz oslobađanje 3-metiladenina, 3-metilguanina, 7-metilguanina i 7-metiladenina
Ovaj enzim učestvuje u uklanjanju alkilisanih baza sa DNK kod Escherichia coli.
Reference[uredi | uredi kod]
- ↑ Evensen, G. and Seeberg, E. (1982). „Adaptation to alkylation resistance involves the induction of a DNA glycosylase”. Nature 296: 773-775. PMID 7040984.
- ↑ Karran, P., Hjelmgren, T. and Lindahl, T. (1982). „Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents”. Nature 296: 770-773. PMID 7040983.
- ↑ Riazuddin, S. and Lindahl, T. (1978). „Properties of 3-methyladenine-DNA glycosylase from Escherichia coli”. Biochemistry 17: 2110-2118. PMID 352392.
- ↑ Thomas, L., Yang, C.-H. and Goldthwait, D.A. (1982). „Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine”. Biochemistry 21: 1162-1169. PMID 7041972.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.