D-alanin—D-serin ligaza

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D-alanin—D-serin ligaza
Identifikatori
EC broj 6.3.2.35
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

D-alanin—D-serin ligaza (EC 6.3.2.35, VanC, VanE, VanG) je enzim sa sistematskim imenom D-alanin:D-serin ligaza (formira ADP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-alanin + D-serin + ATP D-alanil-D-serin + ADP + fosfat

Produkt ovog enzima, D-alanil-D-serin, može da bude inkorporiran u peptidoglikanski pentapeptid umesto uobičajenog D-alanil-D-alanin dipeptida.

Reference[uredi - уреди | uredi izvor]

  1. Dutka-Malen, S., Molinas, C., Arthur, M. and Courvalin, P. (1992). "Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance". Gene 112: 53–58. PMID 1551598. 
  2. Park, I.S., Lin, C.H. and Walsh, C.T. (1997). "Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase". Proc. Natl. Acad. Sci. USA 94: 10040–10044. PMID 9294159. 
  3. Fines, M., Perichon, B., Reynolds, P., Sahm, D.F. and Courvalin, P. (1999). "VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405". Antimicrob. Agents Chemother. 43: 2161–2164. PMID 10471558. 
  4. Depardieu, F., Bonora, M.G., Reynolds, P.E. and Courvalin, P. (2003). "The vanG glycopeptide resistance operon from Enterococcus faecalis revisited". Mol. Microbiol. 50: 931–948. PMID 14617152. 
  5. Watanabe, S., Kobayashi, N., Quinones, D., Hayakawa, S., Nagashima, S., Uehara, N. and Watanabe, N. (2009). "Genetic diversity of the low-level vancomycin resistance gene vanC-2/vanC-3 and identification of a novel vanC subtype (vanC-4) in Enterococcus casseliflavus". Microb. Drug Resist. 15: 1–9. PMID 19216682. 

Literatura[uredi - уреди | uredi izvor]

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