Hondroitin-sulfat-ABC eksolijaza
(Preusmjereno sa stranice ChS ABC lyase II)
| Hondroitin-sulfat-ABC eksolijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.2.21 | ||||||||
| CAS broj | 1000607-06-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hondroitin-sulfat-ABC eksolijaza (EC 4.2.2.21, hondroitinaza, hondroitin ABC eliminaza, hondroitinaza ABC, hondroitin ABC lijaza, hondroitin sulfat ABC lijaza, ChS ABC lijaza, hondroitin sulfat ABC eksoeliminaza, hondroitin sulfat ABC eksolijaza, ChS ABC lijaza II) je enzim sa sistematskim imenom hondroitin-sulfat-ABC eksolijaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Eksolitičko odvajanje Delta4-nezasićenih disaharidnih ostataka sa neredukujućih krajeva polimernih hondroitin/dermatan sulfata i njihovih oligosaharidnih fragmenata.
Ovaj enzim degradira mnoštvo glikozaminoglikana hondroitin-sulfat- i dermatan-sulfatnog tipa.
- ↑ Yamagata, T., Saito, H., Habuchi, O. and Suzuki, S. (1968). „Purification and properties of bacterial chondroitinases and chondrosulfatases”. J. Biol. Chem. 243: 1523-1535. PMID 5647268.
- ↑ Saito, H., Yamagata, T. and Suzuki, S. (1968). „Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates”. J. Biol. Chem. 243: 1536-1542. PMID 4231029.
- ↑ Suzuki, S., Saito, H., Yamagata, T., Anno, K., Seno, N., Kawai, Y. and Furuhashi, T. (1968). „Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion”. J. Biol. Chem. 243: 1543-1550. PMID 5647269.
- ↑ Hamai, A., Hashimoto, N., Mochizuki, H., Kato, F., Makiguchi, Y., Horie, K. and Suzuki, S. (1997). „Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides”. J. Biol. Chem. 272: 9123-9130. PMID 9083041.
- ↑ Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). „Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272: 6276-6286. PMID 16336265.
- ↑ Zhang, Z., Park, Y., Kemp, M.M., Zhao, W., Im, A.R., Shaya, D., Cygler, M., Kim, Y.S. and Linhardt, R.J. (2009). „Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern”. Anal. Biochem. 385: 57-64. PMID 18992215.
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