Brahiurin
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| Brahiurin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.32 | ||||||||
| CAS broj | 848900-32-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Brahiurin (EC 3.4.21.32, proteaza I raka, proteaza II raka) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa širokom specifičnošću za peptidne veze. Prirodni kolagen se razlaže na oko 75% dužine molekula sa N-terminusa. Niska aktivnost na malim molekulskim supstratima tripsina i himotripsina
Ovaj enzim je izolovan iz raka, Uca pugilator.
Reference[uredi | uredi kod]
- ↑ Hurion, N., Fromentin, H. and Keil, B. (1979). „Specificity of the collagenolytic enzyme from the fungus Entomophthora coronata: comparison with the bacterial collagenase from Achromobacter iophagus”. Arch. Biochem. Biophys. 192: 438-445. PMID 219780.
- ↑ Grant, G.A., Eisen, A.Z. and Bradshaw, R.A. (1981). „Collagenolytic protease from fiddler crab (Uca pugilator)”. Methods Enzymol. 80: 722-734.
- ↑ Welgus, H.G., Grant, G.A., Jeffrey, J.J. and Eisen, A.Z. (1982). „Substrate specificity of the collagenolytic serine protease from Uca pugilator: studies with collagenous substrates”. Biochemistry 21: 5183-5189. PMID 6756469.
- ↑ Welgus, H.G. and Grant, G.A. (1983). „Degradation of collagen substrates by a trypsin-like serine protease form the fiddler crab Uca pugilator”. Biochemistry 22: 2228-2233. PMID 6305411.
- ↑ Klimova, O.A., Borukhov, S.I., Solovyeva, N.I., Balaevskaya, T.O. and Strongin, A.Y. (1990). „The isolation and properties of collagenolytic proteases from crab hepatopancreas”. Biochem. Biophys. Res. Commun. 166: 1411-1420. PMID 2154979.
- ↑ Lu, P.-J., Liu, H.-C. and Tsai, I.-H. (1990). „The midgut trypsins of shrimp (Penaeus monodon). High efficiency toward native protein substrates including collagens”. Biol. Chem. Hoppe-Seyler 371: 851-859. PMID 1963309.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.