Beta-amirin 11-oksidaza
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| Beta-amirin 11-oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.134 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Beta-amirin 11-oksidaza (EC 1.14.13.134, ''CYP88D6'') je enzim sa sistematskim imenom beta-amirin,NADPH:kiseonik oksidoreduktaza (hidroksilacija).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- beta-amirin + 2 O2 + 2 NADPH + 2 H+ 11-okso-beta-amirin + 3H2O + 2 NADP+ (sveukupna reakcija)
- (1a) beta-amirin + O2 + NADPH + H+ 11alfa-hidroksi-beta-amirin + H2O + NADP+
- (1b) 11alfa-hidroksi-beta-amirin + O2 + NADPH + H+ 11-okso-beta-amirin + 2H2O + NADP+
Za rad ovog enzim je neophodan citohrom P450. Ovaj enzim učestvuje u biosintezi glicirhizina.
Reference[uredi | uredi kod]
- ↑ Seki, H., Ohyama, K., Sawai, S., Mizutani, M., Ohnishi, T., Sudo, H., Akashi, T., Aoki, T., Saito, K. and Muranaka, T. (2008). „Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin”. Proc. Natl. Acad. Sci. USA 105: 14204-14209. PMID 18779566.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.