Atrolizin E

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Atrolizin E
Identifikatori
EC broj 3.4.24.44
CAS broj 172306-51-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Atrolizin E (EC 3.4.24.44, Crotalus atrox metaloendopeptidaza e, hemoragi, ni toksin e) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje Asn3-Gln, Ser9-His i Ala14-Leu veza u lancu insulina B i Tyr14-Gln i Thr8-Ser u A lancu. Razlaganje tipa IV kolagena na Ala73-Gln u alfa1(IV) i na Gly7-Leu u alfa2(IV)

Ova nehemoragična endopeptidaza je prisutna u venumu zvečarke Crotalus atrox.

Reference[uredi - уреди | uredi izvor]

  1. Bjarnason, J.B. and Tu, A.T. (1978). "Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry 17: 3395–3404. PMID 210790. 
  2. Bjarnason, J.B. and Fox, J.W. (1983). "Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox)". Biochemistry 22: 3770–3778. PMID 6351911. 
  3. Baramova, E.N., Shannon, J.D., Bjarnason, J.B. and Fox, J.W. (1990). "Identification of the cleavave sites by a hemorrhagic metalloproteinase in type IV collagen". Matrix 10: 91–97. PMID 2374521. 

Literatura[uredi - уреди | uredi izvor]

Vanjske veze[uredi - уреди | uredi izvor]