Antranilatna sintaza

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Antranilatna sintaza
1i7q.jpg
Antranilatna sintaza heterotetramer, Serratia marcescens
Identifikatori
EC broj 4.1.3.27
CAS broj 9031-59-8
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Antranilatna sintaza (EC 4.1.3.27, antranilatna sintetaza, horizmatna piruvat-lijaza (amino prihvatajuća), TrpE) je enzim sa sistematskim imenom horizmat piruvat-lijaza (amino prihvatajuća; formira antranilat).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

horizmat + L-glutamin antranilat + piruvat + L-glutamat

U pojedinim organizmima ovaj enzim je deo multifunkcionalnog proteina.

Reference[uredi - уреди | uredi izvor]

  1. Baker, T. and Crawford, I.P. (1966). "Anthranilate synthetase. Partial purification and some kinetic studies on the enzyme from Escherichia coli". J. Biol. Chem. 241: 5577–5584. PMID 5333199. 
  2. Creighton, T.E. and Yanofsky, C. (1970). "Chorismate to tryptophan (Escherichia coli) - anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase". Methods Enzymol. 17A: 365–380. 
  3. Hütter, R., Niederberger, P. and DeMoss, J.A. (1986). "Tryptophan synthetic genes in eukaryotic microorganisms". Annu. Rev. Microbiol. 40: 55–77. PMID 3535653. 
  4. Ito, J. and Yanofsky, C. (1969). "Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits". J. Bacteriol. 97: 734–742. PMID 4886290. 
  5. Zalkin, H. and Kling, D. (1968). "Anthranilate synthetase. Purification and properties of component I from Salmonella typhimurium". Biochemistry 7: 3566–3573. PMID 4878701. 

Literatura[uredi - уреди | uredi izvor]

Vanjske veze[uredi - уреди | uredi izvor]