Alfa-N-acetilgalaktozaminidaza
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| Alfa-N-acetilgalaktozaminidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.49 | ||||||||
| CAS broj | 9075-63-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Alfa-N-acetilgalaktozaminidaza (EC 3.2.1.49, alfa-acetilgalaktozaminidaza, N-acetil-alfa-D-galaktozaminidaza, N-acetil-alfa-galaktozaminidaza, alfa-NAGAL, alfa-NAGA, alfa-GalNAkaza) je enzim sa sistematskim imenom alfa-N-acetil-D-galaktozaminid N-acetilgalaktozaminohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje neredukujućih alfa-(1->3)-N-acetilgalaktozaminskih ostataka sa mucinskih glikoproteina ljudske krvne grupe A i AB, Forsman haptena i lakto serije glikolipida krvne grupe A
Ljudski lizozomalni enzim učestvuje u degradaciji epitopa krvnog tipa A.
Reference[uredi | uredi kod]
- ↑ Asfaw, B., Schindler, D., Ledvinova, J., Cerny, B., Smid, F. and Conzelmann, E. (1998). „Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts”. J. Lipid Res. 39: 1768-1780. PMID 9741689.
- ↑ Zhu, A., Monahan, C., Wang, Z.K. and Goldstein, J. (1996). „Expression, purification, and characterization of recombinant α-N-acetylgalactosaminidase produced in the yeast Pichia pastoris”. Protein Expr. Purif. 8: 456-462. PMID 8954893.
- ↑ Clark, N.E. and Garman, S.C. (2009). „The 1.9 Å structure of human α-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases”. J. Mol. Biol. 393: 435-447. PMID 19683538.
- ↑ Hoskins, L.C., Boulding, E.T. and Larson, G. (1997). „Purification and characterization of blood group A-degrading isoforms of α-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70”. J. Biol. Chem. 272: 7932-7939. PMID 9065462.
- ↑ Harun-Or-Rashid, M., Matsuzawa, T., Satoh, Y., Shiraishi, T., Ando, M., Sadik, G. and Uda, Y. (2010). „Purification and characterization of α-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis”. Biosci. Biotechnol. Biochem. 74: 256-261. PMID 20139603.
- ↑ Weignerova, L., Filipi, T., Manglova, D. and Kren, V. (2008). „Induction, purification and characterization of α-N-acetylgalactosaminidase from Aspergillus niger”. Appl. Microbiol. Biotechnol. 79: 769-774. PMID 18443780.
- ↑ Ashida, H., Tamaki, H., Fujimoto, T., Yamamoto, K. and Kumagai, H. (2000). „Molecular cloning of cDNA encoding α-N-acetylgalactosaminidase from 'Acremonium sp. and its expression in yeast”. Arch. Biochem. Biophys. 384: 305-310. PMID 11368317.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.