Akridon sintaza
| Akridon sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.159 | ||||||||
| CAS broj | 99085-53-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Akridon sintaza (EC 2.3.1.159) je enzim sa sistematskim imenom malonil-KoA:N-metilantraniloil-KoA maloniltransferaza (ciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3 malonil-KoA + N-metilantraniloil-KoA 4 KoA + 1,3-dihidroksi-N-metilakridon + 3 CO2
Ovaj enzim pripada superfamiliji biljnih poliketidnih sintaza.
- ↑ Baumert, A., Maier, W., Gröger, D. and Deutzmann, R. (1994). „Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L”. Z. Naturforsch. C: Biosci. 49: 26-32. PMID 8148006.
- ↑ Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Gröger, D. (1993). „Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures”. Phytochemistry 32: 691-698.
- ↑ Lukačin, R., Springob, K., Urbanke, C., Ernwein, C., Schroder, G., Schroder, J. and Matern, U. (1999). „Native acridone synthases I and II from Ruta graveolens L. form homodimers”. FEBS Lett. 448: 135-140. PMID 10217426.
- ↑ Junghanns, K.T., Kneusel, R.E., Groger, D. and Matern, U. (1998). „Differential regulation and distribution of acridone synthase in Ruta graveolens”. Phytochemistry 49: 403-411. PMID 9747538.
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