Ajmalin
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| (IUPAC) ime | |||
|---|---|---|---|
| (17R,21β)-ajmalan- 17,21-diol ili (1R,9R,10S,13R,14R,16S,18S)- 13-etil- 8-metil- 8,15-diazaheksaciklo [14.2.1.01,9.02,7.010,15.012,17] nonadeka- 2(7),3,5-trien- 14,18-diol | |||
| Klinički podaci | |||
| AHFS/Drugs.com | Internacionalno ime leka | ||
| Identifikatori | |||
| CAS broj | 4360-12-7 | ||
| ATC kod | C01BA05 | ||
| PubChem[1][2] | 20367 | ||
| DrugBank | DB01426 | ||
| ChemSpider[3] | 10469368 | ||
| UNII | 1PON08459R 
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| KEGG[4] | D00199
| ||
| ChEMBL[5] | CHEMBL1230919
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| Hemijski podaci | |||
| Formula | C20H26N2O2 | ||
| Mol. masa | 326,433 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Ajmalin je alkaloid iz klase Ia antiaritmičkih agenasa. On se često koristi za tretman ST elevacija kod pacijenata sa Brugada sindromom.
Ovo jedinjenje je originalno izolovano 1931.[6] iz korena biljke Rauwolfia serpentina. Ime je dobilo po Hakim Ajmal Kanu, čuvenom lekaru iz oblasti Unani medicine u Južnoj Aziji.[7]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Salimuzzaman Siddiqui, Siddiqui, R. H. (1931). J. Indian Chem. Soc. 8: 667–80.
- ↑ Ahmed Nasim Sandilvi (2003), Salimuzzaman Siddiqui: pioneer of scientific research in Pakistan. Daily Dawn. 12 April 2003. Retrieved on 19 July 2007.