Adenozilkobinamid-GDP ribazoltransferaza
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| Adenozilkobinamid-GDP ribazoltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.8.26 | ||||||||
| CAS broj | 137672-85-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Adenozilkobinamid-GDP ribazoltransferaza (EC 2.7.8.26, CobS, kobalaminska sintaza, kobalamin-5'-fosfat sintaza, kobalamin (5'-fosfat) sintaza) je enzim sa sistematskim imenom adenozilkobinamid-GDP:alfa-ribazol ribazoltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) adenozilkobinamid-GDP + alfa-ribazol GMP + adenozilkobalamin
- (2) adenozilkobinamid-GDP + alfa-ribazol 5'-fosfat GMP + adenozilkobalamin 5'-fosfat
Kod Salmonella typhimurium LT2, pri anaerobnim uslovima, CobU (EC 2.7.7.62 i EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) i CobS (EC 2.7.8.26) katalizuje reakcije biosinteze nukleotidne petlje, kojima se konvertuje adenozilkobinamid (AdoCbi) u adenozilkobalamin (AdoCbl).
Reference[uredi | uredi kod]
- ↑ Maggio-Hall, L.A. and Escalante-Semerena, J.C. (1999). „In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes”. Proc. Natl. Acad. Sci. USA 96: 11798-11803. PMID 10518530.
- ↑ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390-412. PMID 12195810.
- ↑ Cameron, B., Blanche, F., Rouyez, M.C., Bisch, D., Famechon, A., Couder, M., Cauchois, L., Thibaut, D., Debussche, L. and Crouzet, J. (1991). „Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5′-phosphate) synthase”. J. Bacteriol. 173: 6066-6073. PMID 1917841.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.