ATP-zavisna NAD(P)H-hidratna dehidrataza
Prijeđi na navigaciju
Prijeđi na pretragu
| ATP-zavisna NAD(P)H-hidratna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.93 | ||||||||
| CAS broj | 116669-08-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
ATP-zavisna NAD(P)H-hidratna dehidrataza (EC 4.2.1.93, redukovani nikotinamid adenin dinukleotid hidratna dehidrataza, ATP-zavisna H4NAD(P)+OH dehidrataza, (6S)-beta-6-hidroksi-1,4,5,6-tetrahidronikotinamid-adenin-dinukleotid hidrolijaza (ATP-hidroliza), (6S)-6-beta-hidroksi-1,4,5,6-tetrahidronikotinamid-adenin-dinukleotid hidrolijaza (ATP hidroliza, formira NADH)) je enzim sa sistematskim imenom (6S)-6beta-hidroksi-1,4,5,6-tetrahidronikotinamid-adenin-dinukleotid hidrolijaza (ATP-hidroliza, formira NADH).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) ATP + (6S)-6beta-hidroksi-1,4,5,6-tetrahidronikotinamid-adenin dinukleotid ADP + fosfat + NADH
- (2) ATP + (6S)-6beta-hidroksi-1,4,5,6-tetrahidronikotinamid-adenin dinukleotid fosfat ADP + fosfat + NADPH
Ovaj enzim deluje jednakom brzinom na hidratisani NADH i hidratisani NADPH.
Reference[uredi | uredi kod]
- ↑ Meinhart, J.O., Chaykin, S. and Krebs, E.G. (1956). „Enzymatic conversion of a reduced diphosphopyridine nucleotide derivative to reduced diphosphopyridine nucleotide”. J. Biol. Chem. 220: 821-829. PMID 13331940.
- ↑ Regueiro Varela, B., Amelunxen, R. and Grisolia, S. (1970). „Synthesis and degradation of monohydroxytetrahydronicotinamide adenine dinucleotide phosphate”. Physiol. Chem. Phys. 2: 445-454.
- ↑ Acheson, S.A., Kirkman, H.N. and Wolfenden, R. (1988). „Equilibrium of 5,6-hydration of NADH and mechanism of ATP-dependent dehydration”. Biochemistry 27: 7371-7375. PMID 3061454.
- ↑ Marbaix, A.Y., Noel, G., Detroux, A.M., Vertommen, D., Van Schaftingen, E. and Linster, C.L. (2011). „Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair”. J. Biol. Chem. 286: 41246-41252. PMID 21994945.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.