Prostaglandin-E2 9-reduktaza
| Prostaglandin-E2 9-reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.189 | ||||||||
| CAS broj | 42613-35-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prostaglandin-E2 9-reduktaza (EC 1.1.1.189, PGE2-9-OR, reduktaza, 15-hidroksi-9-oksoprostaglandin, 9-keto-prostaglandin E2 reduktaza, 9-ketoprostaglandin reduktaza, PGE-9-ketoreduktaza, PGE2 9-oksoreduktaza, PGE2-9-ketoreduktaza, prostaglandin 9-ketoreduktaza, prostaglandin E 9-ketoreduktaza, prostaglandin E2-9-oksoreduktaza) je enzim sa sistematskim imenom (5Z,13E)-(15S)-9alfa,11alfa,15-trihidroksiprosta-5,13-dienoat:NADP+ 9-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5Z,13E)-(15S)-9alfa,11alfa,15-trihidroksiprosta-5,13-dienoat + NADP+ (5Z,13E)-(15S)-11alfa,15-dihidroksi-9-oksoprosta-5,13-dienoat + NADPH + H+
Ovaj enzim redukuje prostaglandin E2 do prostaglandina F2alfa. Brojni drugi 9-okso- i 15-okso-prostaglandinski derivati takođe mogu da budu redukovani do korespondirajućih hidroksi jedinjenja. Može da bude identičan sa EC 1.1.1.197, 15-hidroksiprostaglandin dehidrogenazom (NADP+).
Reference[uredi | uredi kod]
- ↑ Lee, S.-C. and Levine, L. (1975). „Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase”. J. Biol. Chem. 250: 4549-4555. PMID 166995.
- ↑ Schlegel, W., Krüger, S. and Korte, K. (1984). „Purification of prostaglandin E2 9-oxoreductase from human decidua vera”. FEBS Lett. 171: 141-144. PMID 6586494.
- ↑ Tai, H.-H. and Yuan, B. (1982). „Purification and assay of 9-hydroxyprostaglandin dehydrogenase from rat kidney”. Methods Enzymol. 86: 113-117. PMID 7132747.
- ↑ Watkins, J.D. and Jarabak, J. (1985). „The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney”. Prostaglandins 30: 335-349. PMID 3901124.
Literatura[uredi | uredi kod]
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- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
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