5-(Karboksiamino)imidazolna ribonukleotid mutaza
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| 5-(Karboksiamino)imidazolna ribonukleotid mutaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.18 | ||||||||
| CAS broj | 255379-40-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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5-(Karboksiamino)imidazolna ribonukleotid mutaza (EC 5.4.99.18, N5-CAIR mutaza, PurE, N5-karboksiaminoimidazol ribonukleotidna mutaza, klasa I PurE) je enzim sa sistematskim imenom 5-karboksiamino-1-(5-fosfo-D-ribozil)imidazol karboksimutaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-karboksiamino-1-(5-fosfo-D-ribozil)imidazol 5-amino-1-(5-fosfo-D-ribozil)imidazol-4-karboksilat
Kod eubakterija, gljiva i biljiki, ovaj enzim, zajedno sa EC 6.3.4.18, 5-(karboksiamino)imidazol ribonukleotidnom sintazom, je nephodan za izvođenje reakcije koju katalizuje enzim EC 4.1.1.21, fosforibozilaminoimidazolna karboksilaza, kod kičmenjaka.
Reference[uredi | uredi kod]
- ↑ Meyer, E., Leonard, N.J., Bhat, B., Stubbe, J. and Smith, J.M. (1992). „Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway”. Biochemistry 31: 5022-5032. PMID 1534690.
- ↑ Mueller, E.J., Meyer, E., Rudolph, J., Davisson, V.J. and Stubbe, J. (1994). „N5-Carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli”. Biochemistry 33: 2269-2278. PMID 8117684.
- ↑ Meyer, E., Kappock, T.J., Osuji, C. and Stubbe, J. (1999). „Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase”. Biochemistry 38: 3012-3018. PMID 10074353.
- ↑ Mathews, I.I., Kappock, T.J., Stubbe, J. and Ealick, S.E. (1999). „Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway”. Structure 7: 1395-1406. PMID 10574791.
- ↑ Firestine, S.M., Poon, S.W., Mueller, E.J., Stubbe, J. and Davisson, V.J. (1994). „Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms”. Biochemistry 33: 11927-11934. PMID 7918411.
- ↑ Firestine, S.M., Misialek, S., Toffaletti, D.L., Klem, T.J., Perfect, J.R. and Davisson, V.J. (1998). „Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis”. Arch. Biochem. Biophys. 351: 123-134. PMID 9500840.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.