4-Oksalmesakonatna hidrataza
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| 4-Oksalmesakonatna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.83 | ||||||||
| CAS broj | 85204-95-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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4-Oksalmesakonatna hidrataza (EC 4.2.1.83, 4-oksalmesakonatksa hidrataza, 4-karboksi-2-oksoheksenedioatna hidrataza, 4-karboksi-2-oksobutan-1,2,4-trikarboksilat 2,3-hidrolijaza, oksalmesakonatna hidrataza, gama-oksalmesakonatna hidrataza, 2-hidroksi-4-oksobutan-1,2,4-trikarboksilat 2,3-hidrolijaza, LigJ, GalB) je enzim sa sistematskim imenom (1E,3E)-4-hidroksibuta-1,3-dien-1,2,4-trikarboksilat 1,2-hidrolijaza (formira 2-hidroksi-4-oksobutan-1,2,4-trikarboksilat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-hidroksi-4-oksobutan-1,2,4-trikarboksilat (1E,3E)-4-hidroksibuta-1,3-dien-1,2,4-trikarboksilat + H2O
Ovaj enzim učestvuje u degradaiji protokatehuata.
Reference[uredi | uredi kod]
- ↑ Maruyama, K. (1983). „Enzymes responsible for degradation of 4-oxalmesaconic acid in Pseudomonas ochraceae”. J. Biochem. 93: 567-574. PMID 6841354.
- ↑ Maruyama, K. (1985). „Purification and properties of γ-oxalomesaconate hydratase from Pseudomonas ochraceae grown with phthalate”. Biochem. Biophys. Res. Commun. 128: 271-277. PMID 3985968.
- ↑ Hara, H., Masai, E., Katayama, Y. and Fukuda, M. (2000). „The 4-oxalomesaconate hydratase gene, involved in the protocatechuate 4,5-cleavage pathway, is essential to vanillate and syringate degradation in Sphingomonas paucimobilis SYK-6”. J. Bacteriol. 182: 6950-6957. PMID 11092855.
- ↑ Nogales, J., Canales, A., Jimenez-Barbero, J., Serra, B., Pingarron, J.M., Garcia, J.L. and Diaz, E. (2011). „Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida”. Mol. Microbiol. 79: 359-374. PMID 21219457.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.