4-Hidroksibenzoat 3-monooksigenaza

4-hidroksibenzoat 3-monooksigenaza
Identifikatori
EC broj	1.14.13.2
CAS broj	9059-23-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	structures
Pretraga PMC articles PubMed articles NCBI Protein search

4-hidroksibenzoat 3-monooksigenaza (EC 1.14.13.2, p-hidroksibenzoatna hidrolijaza, p-hidroksibenzoatna hidroksilaza, 4-hidroksibenzoatna 3-hidroksilaza, 4-hidroksibenzoatna monooksigenaza, 4-hidroksibenzoinska hidroksilaza, p-hidroksibenzoat-3-hidroksilaza, p-hidroksibenzojeva kiselina hidrolaza, p-hidroksibenzojeva hidroksilaza) je enzim sa sistematskim imenom 4-hidroksibenzoat,NADPH:kiseonik oksidoreduktaza (3-hidroksilacija). Ovaj enzim katalizuje sledeću hemijsku reakciju

4-hidroksibenzoat + NADPH + H⁺ + O₂ $\rightleftharpoons$ protokatehuat + NADP⁺ + H₂O

Ovaj enzim je flavoprotein (FAD). Većina enzima iz Pseudomonas su visoko specifični za NADPH (cf. EC 1.14.13.33, 4-hidroksibenzoat 3-monooksigenaza [NAD(P)H]).

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. http://books.google.com/books/about/Fundamentals_of_enzymology.html?id=8uvwAAAAMAAJ. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. http://books.google.com/books/about/Advances_in_Enzymology_and_Related_Areas.html?id=Pmh8yToeuloC. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. http://books.google.com/books/about/Enzyme_Kinetics.html?id=T60oAAAAYAAJ. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. http://books.google.com/books/about/Evaluation_of_Enzyme_Inhibitors_in_Drug.html?id=l2rMy8QNUk0C. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. http://books.google.com/books/about/Biochemical_pathways.html?id=081qAAAAMAAJ. 

Spoljašnje veze

• MeSH 4-hydroxybenzoate+3-monooxygenase