3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza
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| 3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.107 | ||||||||
| CAS broj | 152787-68-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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3a,7a,12a-trihidroksi-5b-holest-24-enoil-KoA dehidrataza (EC 4.2.1.107, 46 kDa hidrataza 2, (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA hidrolijaza) je enzim sa sistematskim imenom (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA hidrolijaza (formira (24E)-3alfa,7alfa,12alfa-trihidroksi-5beta-holest-24-enoil-KoA).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (24R,25R)-3alfa,7alfa,12alfa,24-tetrahidroksi-5beta-holestanoil-KoA (24E)-3alfa,7alfa,12alfa-trihidroksi-5beta-holest-24-enoil-KoA + H2O
Ovaj enzim je deo peroksizomalnog multifunktionalnog enzim perMFE-2 kod pacova.
Reference[uredi | uredi kod]
- ↑ Qin, Y.M., Haapalainen, A.M., Conry, D., Cuebas, D.A., Hiltunen, J.K. and Novikov, D.K. (1997). „Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis”. Biochem. J. 328: 377-382. PMID 9371691.
- ↑ Xu, R. and Cuebas, D.A. (1996). „The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids”. Biochem. Biophys. Res. Commun. 221: 271-278. PMID 8619845.
- ↑ Kinoshita, T., Miyata, M., Ismail, S.M., Fujimoto, Y., Kakinuma, K., Kokawa, N.I. and Morisaki, M. (1988). „Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid”. Chem. Pharm. Bull. 36: 134-141.
- ↑ Fujimoto, Y., Kinoshita, T., Oya, I., Kakinuma, K., Ismail, S.M., Sonoda, Y., Sato, Y. and Morisaki, M. (1988). „Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3α,7α,12α,24-tetrahydroxy-5β-cholestan-26-oic acid and cholic acid”. Chem. Pharm. Bull. 36: 142-145.
- ↑ Kurosawa, T., Sato, M., Nakano, H., Fujiwara, M., Murai, T., Yoshimura, T. and Hashimoto, T. (2001). „Conjugation reactions catalyzed by bifunctional proteins related to β-oxidation in bile acid biosynthesis”. Steroids 66: 107-114. PMID 11146090.
- ↑ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137-174. PMID 12543708.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.