2-oksoaldehid dehidrogenaza (NAD+)
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| 2-oksoaldehid dehidrogenaza (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.23 | ||||||||
| CAS broj | 37250-91-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-oksoaldehid dehidrogenaza (NAD+) (EC 1.2.1.23, alfa-ketoaldehidna dehidrogenaza, metilglioksalna dehidrogenaza, NAD+-vezana alfa-ketoaldehidna dehidrogenaza, 2-ketoaldehidna dehidrogenaza, NAD+-zavisna alfa-ketoaldehidna dehidrogenaza) je enzim sa sistematskim imenom 2-oksoaldehid:NAD+ 2-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-oksoaldehid + NAD+ +H2O 2-okso karboksilat + NADH + H+
Ova enzim nije identičan sa EC 1.2.1.49, 2-oksoaldehidnom dehidrogenazom (NADP+).
Reference[uredi | uredi kod]
- ↑ Monder, C. (1967). „α-Keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate”. J. Biol. Chem. 242: 4603-4609. PMID 4383524.
- ↑ Ray, M. and Ray, S. (1982). „On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase”. J. Biol. Chem. 257: 10571-10574. PMID 7107626.
- ↑ Ray, S. and Ray, M. (1982). „Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate”. J. Biol. Chem. 257: 10566-10570. PMID 7107625.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.