2-dehidropantolakton reduktaza (A-specific)
| 2-dehidropantolakton reduktaza (A-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.168 | ||||||||
| CAS broj | 37211-75-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2-dehidropantolakton reduktaza (A-specific) (EC 1.1.1.168, 2-oksopantoil laktonska reduktaza, ketopantoil laktonska reduktaza, 2-ketopantoil laktonska reduktaza, 2-dehidropantoil-laktonska reduktaza (A-specifična)) je enzim sa sistematskim imenom (R)-pantolakton:NADP+ oksidoreduktaza (A-specifična).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (R)-pantolakton + NADP+ 2-dehidropantolakton + NADPH + H+
Enzim iz kvasca se razlikuje od enzima iz Escherichia coli (EC 1.1.1.214, 2-dehidropantolakton reduktaza (B-specifična)), koji je specifičan za B-stranu NADP+, i u pogledu receptorskih zahteva od EC 1.1.99.26, 3-hidroksicikloheksanonske dehidrogenaze.
- ↑ King, H.L., Jr. and Wilken, D.R. (1972). „Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase”. J. Biol. Chem. 247: 4689-4695. PMID 4603075.
- ↑ Wilken, D.R., King, H.L., Jr. and Dyar, R.E. (1975). „Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate”. J. Biol. Chem. 250: 2311-2314. PMID 234966.
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