2-Hidroksiizoflavanon sintaza
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| 2-Hidroksiizoflavanon sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.86 | ||||||||
| CAS broj | 168680-18-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Hidroksiizoflavanon sintaza (EC 1.14.13.86, 2-hidroksiizoflavanonska sintaza) je enzim sa sistematskim imenom apigenin,NADPH:kiseonik oksidoreduktaza (formira izoflavanon).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- apigenin + 2 NADPH + 2 H+ + O2 2-hidroksi-2,3-dihidrogenistein + 2 NADP+ +H2O
Ovaj enzim je hem-tiolatni protein (P-450).
Reference[uredi | uredi kod]
- ↑ Kochs, G. and Grisebach, H. (1986). „Enzymic synthesis of isoflavones”. Eur. J. Biochem. 155: 311-318. PMID 3956488.
- ↑ Steele, C. (1999). „L., Gijzen, M., Qutob, D. and Dixon, R.A. Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean”. Arch. Biochem. Biophys. 367: 146-150. PMID 10375412.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.