2-C-metil-D-eritritol 2,4-ciklodifosfatna sintaza
| 2-C-metil-D-eritritol 2,4-ciklodifosfatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.6.1.12 | ||||||||
| CAS broj | 287480-92-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-C-metil-D-eritritol 2,4-ciklodifosfatna sintaza (EC 4.6.1.12, MECDP-sintaza, 2-fosfo-4-(citidin 5'-difosfo)-2-C-metil-D-eritritol CMP-lijaza (ciklizacija)) je enzim sa sistematskim imenom 2-fosfo-4-(citidin 5'-difosfo)-2-C-metil-D-eritritol CMP-lijaza (ciklizacija, formira 2-C-metil-D-eritritol 2,4-ciklodifosfat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-fosfo-4-(citidin 5'-difosfo)-2-C-metil-D-eritritol 2-C-metil-D-eritritol 2,4-ciklodifosfat + CMP
Za dejstvo enzima iz Escherichia coli neophodan je jon Mg2+ ili Mn2+.
- ↑ Herz, S., Wungsintaweekul, J., Schuhr, C.A., Hecht, S., Lüttgen, H., Sagner, S., Fellermeier, M., Eisenreich, W., Zenk, M.H., Bacher, A. and Rohdich, F. (2000). „Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erithritol 2-phosphate to 2-C-methyl-D-erithritol 2,4-cyclodiphosphate”. Proc. Natl. Acad. Sci. USA 97: 2486-2490. PMID 10694574.
- ↑ Takagi, M., Kuzuyama, T., Kaneda, K., Watanabe, H., Dairi, T. and Seto, H. (2000). „Studies on the nonmevalonate pathway: Formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol”. Tetrahedron Lett. 41: 3395-3398.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.