2,4-diaminopentanoat dehidrogenaza
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| 2,4-diaminopentanoat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.1.12 | ||||||||
| CAS broj | 39346-26-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2,4-diaminopentanoat dehidrogenaza (EC 1.4.1.12, 2,4-diaminopentanoatna kiselina C4 dehidrogenaza) je enzim sa sistematskim imenom 2,4-diaminopentanoat:NAD(P)+ oksidoreduktaza (deaminacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2,4-diaminopentanoat +H2O + NAD(P)+ 2-amino-4-oksopentanoat + NH3 + NAD(P)H + H+
Ovaj enzim takođe deluje, mada sporo, na 2,5-diaminoheksanoat i formira 2-amino-5-oksoheksanoat.
Reference[uredi | uredi kod]
- ↑ Somack, R. and Costilow, R.N. (1973). „2,4-Diaminopentanoic acid C4 dehydrogenase. Purification and properties of the protein”. J. Biol. Chem. 248: 385-388. PMID 4684685.
- ↑ Stadtman, T.C. (1973). „Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase)”. Adv. Enzymol. Relat. Areas Mol. Biol. 38: 441-445.
- ↑ Tsuda, Y. and Friedmann, H.C. (1970). „Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide”. J. Biol. Chem. 245: 5914-5926. PMID 4394942.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.