2,3-Dihidroksibenzoat-serinska ligaza

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2,3-Dihidroksibenzoat-serinska ligaza
Identifikatori
EC broj 6.3.2.14
CAS broj 37318-63-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

2,3-Dihidroksibenzoat-serinska ligaza (EC 6.3.2.14, N-(2,3-dihidroksibenzoil)-serin sintetaza, 2,3-dihidroksibenzoilserin sintetaza, 2,3-dihidroksibenzoat—serin ligaza) je enzim sa sistematskim imenom 2,3-dihidroksibenzoat:L-serin ligaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

6 ATP + 3 2,3-dihidroksibenzoat + 3 L-serin enterobactin + 6 AMP + 6 difosfat

Ovaj enzimski kompleks katalizuje konverziju molekula koji se formiraju siderofori enterobaktina.

Reference[uredi - уреди | uredi izvor]

  1. Brot, N. and Goodwin, J. (1968). "Regulation of 2,3-dihydroxybenzoylserine synthetase by iron". J. Biol. Chem. 243: 510–513. PMID 4966114. 
  2. Rusnak, F., Faraci, W.S. and Walsh, C.T. (1989). "Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product". Biochemistry 28: 6827–6835. PMID 2531000. 
  3. Rusnak, F., Liu, J., Quinn, N., Berchtold, G.A. and Walsh, C.T. (1990). "Subcloning of the enterobactin biosynthetic gene entB: expression, purification, characterization, and substrate specificity of isochorismatase". Biochemistry 29: 1425–1435. PMID 2139796. 
  4. Rusnak, F., Sakaitani, M., Drueckhammer, D., Reichert, J. and Walsh, C.T. (1991). "Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine". Biochemistry 30: 2916–2927. PMID 1826089. 
  5. Gehring, A.M., Mori, I. and Walsh, C.T. (1998). "Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF". Biochemistry 37: 2648–2659. PMID 9485415. 
  6. Shaw-Reid, C.A., Kelleher, N.L., Losey, H.C., Gehring, A.M., Berg, C. and Walsh, C.T. (1999). "Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization". Chem. Biol. 6: 385–400. PMID 10375542. 

Literatura[uredi - уреди | uredi izvor]

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