1-Dezoksi-D-ksiluloza-5-fosfat sintaza
| 1-Dezoksi-D-ksiluloza-5-fosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.2.1.7 | ||||||||
| CAS broj | 202218-79-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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1-Dezoksi-D-ksiluloza-5-fosfat sintaza (EC 2.2.1.7, 1-dezoksi-D-ksiluloza-5-fosfat piruvat-lijaza (karboksilacija), DXP-sintaza) je enzim sa sistematskim imenom piruvat:D-gliceraldehid-3-fosfat acetaldehidtransferaza (dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- piruvat + D-gliceraldehid 3-fosfat 1-dezoksi-D-ksiluloza 5-fosfat + CO2
Za dejstvo ovog enzima je neophodan tiamin difosfat. Ovaj enzim je deo alternativnog nonmevalonatnog puta za biosintezu terpenoida.
- ↑ Sprenger, G.A., Schörken, U., Weigert, T., Grolle, S., deGraaf, A.A., Taylor, S.V., Begley, T.P., Bringer-Meyer, S. and Sahm, H. (1997). „Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol”. Proc. Natl. Acad. Sci. USA 94: 12857-12862. PMID 9371765.
- ↑ Kuzuyama, T., Takagi, M., Takahashi, S. and Seto, H. (2000). „Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis”. J. Bacteriol. 182: 891-897. PMID 10648511.
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