(S)-norkoklaurinska sintaza
| (S)-norkoklaurinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.78 | ||||||||
| CAS broj | 79122-01-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(S)-norkoklaurinska sintaza (EC 4.2.1.78, (S)-norlaudanozolinska sintaza, 4-hidroksifenilacetaldehidna hidrolijaza (dodaje dopamin)) je enzim sa sistematskim imenom 4-hidroksifenilacetaldehid hidrolijaza (dodaje dopamin, formira (S)-norkoklaurin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-hidroksifenilacetaldehid + dopamin (S)-norkoklaurin + H2O
Ovom reakcijom nastaje šestočlani prsten putem formiranja veze između C-6 sa 3,4-dihidroksifenilne grupe dopamina i C-1 aldehida u iminu formiranom između supstrata.
- ↑ Stadler, R., Zenk, M.H. (1990). „A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline”. Liebigs Ann. Chem.: 555-562.
- ↑ Stadler, R., Kutchan, T.M., Zenk, M.H. (1989). „(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis”. Phytochemistry 28: 1083-1086.
- ↑ Samanani, N. and Facchini, P.J. (2002). „Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants”. J. Biol. Chem. 277: 33878-33883. PMID 12107162.
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