(N-acetilneuraminil)-galaktozilglukozilkeramid N-acetilgalaktozaminiltransferaza
| (N-acetilneuraminil)-galaktozilglukozilkeramid N-acetilgalaktozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.92 | ||||||||
| CAS broj | 67338-98-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(N-acetilneuraminil)-galaktozilglukozilkeramid N-acetilgalaktozaminiltransferaza (EC 2.4.1.92, uridin difosfoacetilgalaktozamin-gangliozid GM3 acetilgalaktozaminiltransferaza, gangliozid GM2 sintaza, gangliozid GM3 acetilgalaktozaminiltransferaza, GM2 sintaza, UDP acetilgalaktozamin-(N-acetilneuraminil)-D-galaktozil-D-glukozilkeramid acetilgalaktozaminiltransferaza, UDP-N-acetil-D-galaktozamin:1-O-(O-(N-acetil-alfa-neuraminil)-(2->3)-O-beta-D-galaktopiranozil-(1->4)-beta-D-glukopiranozil)-keramid 1,4-beta-N-acetil-D-galaktozaminiltransferaza acetilgalaktozaminiltransferaza, UDP-N-acetilgalaktozamin GM3 N-acetilgalaktozaminiltransferaza, uridin difosfoacetilgalaktozamin-acetilneuraminilgalaktozilglukozilkeramid acetilgalaktozaminiltransferaza, uridin difosfoacetilgalaktozamin-hematozid acetilgalaktozaminiltransferaza, GM2/GD2-sintaza, beta-1,4N-aetilgalaktozaminiltransferaza, asialo-GM2 sintaza, GalNAc-T, UDP-N-acetil-D-galaktozamin:(N-acetilneuraminil)-D-galaktozil-D-glukozilkeramid N-acetil-D-galaktozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-galaktozamin:1-O-(O-(N-acetil-alfa-neuraminil)-(2->3)-O-beta-D-galaktopiranosil-(1->4)-beta-D-glukopiranosil)-keramid 4-beta-N-acetil-D-galaktozaminiltransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-galaktozamin + 1-O-[O-(N-acetil-alfa-neuraminil)-(2->3)-O-beta-D-galaktopiranozil-(1->4)-beta-D-glukopiranozil]-keramid UDP + 1-O-[O-2-(acetilamino)-2-dezoksi-beta-D-galaktopiranozil-(1->4)-O-[N-acetil-alfa-neuraminil-(2->3)]-O-beta-D-galaktopiranozil-(1->4)-beta-D-glukopiranozil]-keramid
Ovaj enzim katalizuje formiranje gangliozida.
Reference[uredi | uredi kod]
- ↑ Dicesare, J.L. and Dain, J.A. (1971). „The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain”. Biochim. Biophys. Acta 231: 385-393. PMID 5554906.
- ↑ Pohlentz, G., Klein, D., Schwarzmann, G., Schmitz, D. and Sandhoff, K. (1988). „Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver”. Proc. Natl. Acad. Sci. USA 85: 7044-7048. PMID 3140234.
- ↑ Kazuya, I.-P., Hidari, J.K., Ichikawa, S., Furukawa, K., Yamasaki, M. and Hirabayashi, Y. (1994). „β1-4N-Acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a β1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F”. Biochem. J. 303: 957-965. PMID 7980468.
- ↑ Hashimoto, Y., Sekine, M., Iwasaki, K. and Suzuki, A. (1993). „Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver”. J. Biol. Chem. 268: 25857-25864. PMID 8245020.
- ↑ Nagai, K. and Ishizuka, I. (1987). „Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain”. J. Biochem. (Tokyo) 101: 1115-1127. PMID 3115968.
- ↑ Furukawa, K., Takamiya, K. and Furukawa, K. (2002). „β1,4-N-Acetylgalactosaminyltransferase—GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides”. Biochim. Biophys. Acta 1573: 356-362. PMID 12417418.
- ↑ Yamashita, T., Wu, Y.P., Sandhoff, R., Werth, N., Mizukami, H., Ellis, J.M., Dupree, J.L., Geyer, R., Sandhoff, K. and Proia, R.L. (2005). „Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions”. Proc. Natl. Acad. Sci. USA 102: 2725-2730. PMID 15710896.
Literatura[uredi | uredi kod]
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