(Metionin sintaza) reduktaza
| (metionin sintaza) reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.16.1.8 | ||||||||
| CAS broj | 207004-87-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(metionin sintaza) reduktaza (EC 1.16.1.8, metioninska sintaza kob(II)alaminska reduktaza (metilacija), metioninska sintaza reduktaza, (metioninska sintaza)-kobalaminska metiltransferaza (kob(II)alaminska redukcija)) je enzim sa sistematskim imenom (metionin sintaza)-metilkob(I)alamin,S-adenozilhomocistein:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 [metionin sintaza]-metilkob(I)alamin + 2 S-adenozilhomocistein + NADP+ 2 [metionin sintaza]-kob(II)alamin + NADPH + H+ + 2 S-adenozil-L-metionin
Kod ljudi je ovaj enzim flavoprotein koji sadrži FAD i FMN.
- ↑ Leclerc, D., Wilson, A., Dumas, R., Gafuik, C., Song, D., Watkins, D., Heng, H.H.Q., Rommens, J.M., Scherer, S.W., Rosenblatt, D.S., Gravel, R.A. (1998). „Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria”. Proc. Natl. Acad. Sci. USA 95: 3059-3064. PMID 9501215.
- ↑ Olteanu, H. and Banerjee, R. (2001). „Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation”. J. Biol. Chem. 276: 35558-35563. PMID 11466310.
- ↑ Olteanu, H., Munson, T. and Banerjee, R. (2002). „Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase”. Biochemistry 41: 13378-13385. PMID 12416982.
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