(Heparan sulfat)-glukozamin 3-sulfotransferaza 1
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| (heparan sulfat)-glukozamin 3-sulfotransferaza 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.2.23 | ||||||||
| CAS broj | 183257-54-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(heparan sulfat)-glukozamin 3-sulfotransferaza 1 (EC 2.8.2.23, heparin-glukozaminska 3-O-sulfotransferaza, 3'-fosfoadenilil-sulfat:heparin-glukozamin 3-O-sulfotransferaza, glukozaminilna 3-O-sulfotransferaza, heparan sulfat D-glukozaminilna 3-O-sulfotransferaza, izoform/izozim 1 (3-OST-1, HS3ST1)) je enzim sa sistematskim imenom 3'-fosfoadenilil-sulfat:(heparan sulfat)-glukozamin 3-sulfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3'-fosfoadenilil sulfat + [heparan sulfat]-glukozamin adenozin 3',5'-bisfosfat + [heparan sulfat]-glukozamin 3-sulfat
Ovaj enzim je veoma selektivan za prekurzor antitrombin-vezujućeg mesta.
Reference[uredi | uredi kod]
- ↑ Kusche, M., Backström, G., Riesenfeld, J., Pepitou, M., Choay, J. and Lindahl, U. (1988). „Biosynthesis of heparin. O-Sulfation of the antithrombin-binding region”. J. Biol. Chem. 263: 15474-15484. PMID 3139669.
- ↑ Shworak, N.W., Fritze, L.M.S., Liu, J., Butler, L.D. and Rosenberg, R.D. (1996). „Cell-free synthesis of anticoagulant heparan sulfate reveals a limiting activity which modifies a nonlimiting precursor pool”. J. Biol. Chem. 271: 27063-27071. PMID 8900197.
- ↑ Liu, J., Shworak, N.W., Fritze, L.M.S., Edelberg, J.M. and Rosenberg, R.D. (1996). „Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase”. J. Biol. Chem. 271: 27072-27082. PMID 8900198.
- ↑ Shworak, N.W., Liu, J., Fritze, L.M.S., Schwartz, J.J., Zhang, L., Logeart, D. and Rosenberg, R.D. (1997). „Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase”. J. Biol. Chem. 272: 28008-28019. PMID 9346953.
- ↑ Zhang, L., Yoshida, K., Liu, J. and Rosenberg, R.D. (1999). „Anticoagulant heparan sulfate precursor structures in F9 embryonal carcinoma cells”. J. Biol. Chem. 274: 5681-5691. PMID 10026187.
- ↑ Zhang, L., Lawrence, R., Schwartz, J.J., Bai, X. (2001). „, Wei., G, Esko, J.D. and Rosenberg, R.D. The effect of precursor structures on the action of glucosaminyl 3-O-sulfotransferase-1 and the biosynthesis of anticoagulant heparan sulfate”. J. Biol. Chem. 276: 28806-28813. PMID 11375390.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.