INHBB
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| edit |
| Inhibin, beta B | |||||||||||
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| Identifikatori | |||||||||||
| Simbol | INHBB | ||||||||||
| Vanjski ID | OMIM: 147390 MGI: 96571 HomoloGene: 1654 GeneCards: INHBB Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3625 | 16324 | |||||||||
| Ensembl | ENSG00000163083 | ENSMUSG00000037035 | |||||||||
| UniProt | P09529 | Q04999 | |||||||||
| RefSeq (mRNA) | NM_002193.2 | NM_008381.3 | |||||||||
| RefSeq (protein) | NP_002184.2 | NP_032407.1 | |||||||||
| Lokacija (UCSC) | Chr 2: 121.1 - 121.11 Mb | Chr 1: 119.42 - 119.42 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Inhibin, beta B (INHBB) je protein koji je kod ljudi kodiran INHBB genom.[1][2] INHBB je podjedinica u aktivinu i inhibinu, blisko srodnim glikoproteinima sa suprotnim biološkim destvima.
Funkcija[uredi | uredi kod]
Inhibini su heterodimerni glikoproteini koji se sastoje od α podjedinice (INHA) i jedne od dve homologne, ali različite, β podjedinice (βA ili βB, ovog proteina). iRNK za dve podjedinice je prisutna u jajnicima odraslih pacova.[3] Inhibin se može specifično vezati za testikularne interstinalne ćelije tokom razvića i ima značajnu ulogu u regulaciji produkcije testosterona Lejdigovih ćelija ili funkcionisanju interstitinalnih ćelija.[4]
Reference[uredi | uredi kod]
- ↑ Burger HG, Igarashi M (April 1988). „Inhibin: definition and nomenclature, including related substances”. Endocrinology 122 (4): 1701–2. DOI:10.1210/endo-122-4-1701. PMID 3345731.
- ↑ „Entrez Gene: INHBB inhibin, beta B (activin AB beta polypeptide)”.
- ↑ Feng ZM, Bardin CW, Chen CL (June 1989). „Characterization and regulation of testicular inhibin beta-subunit mRNA”. Mol. Endocrinol. 3 (6): 939–48. DOI:10.1210/mend-3-6-939. PMID 2739657.
- ↑ Krummen LA, Moore A, Woodruff TK, Covello R, Taylor R, Working P, Mather JP (April 1994). „Localization of inhibin and activin binding sites in the testis during development by in situ ligand binding”. Biol. Reprod. 50 (4): 734–44. DOI:10.1095/biolreprod50.4.734. PMID 8199254.
Literatura[uredi | uredi kod]
- Ying SY (1988). „Inhibins and activins: chemical properties and biological activity.”. Proc. Soc. Exp. Biol. Med. 186 (3): 253–64. PMID 3122219.
- Munz B, Hübner G, Tretter Y, et al. (1999). „A novel role of activin in inflammation and repair.”. J. Endocrinol. 161 (2): 187–93. DOI:10.1677/joe.0.1610187. PMID 10320815.
- Welt CK (2002). „The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction.”. Curr. Opin. Obstet. Gynecol. 14 (3): 317–23. DOI:10.1097/00001703-200206000-00012. PMID 12032389.
- Shav-Tal Y, Zipori D (2003). „The role of activin a in regulation of hemopoiesis.”. Stem Cells 20 (6): 493–500. DOI:10.1634/stemcells.20-6-493. PMID 12456957.
- Lahlou N, Roger M (2005). „Inhibin B in pubertal development and pubertal disorders.”. Semin. Reprod. Med. 22 (3): 165–75. DOI:10.1055/s-2004-831892. PMID 15319819.
- Mathews LS, Vale WW (1991). „Expression cloning of an activin receptor, a predicted transmembrane serine kinase.”. Cell 65 (6): 973–82. DOI:10.1016/0092-8674(91)90549-E. PMID 1646080.
- Schmelzer CH, Burton LE, Tamony CM, et al. (1990). „Purification and characterization of recombinant human activin B.”. Biochim. Biophys. Acta 1039 (2): 135–41. DOI:10.1016/0167-4838(90)90178-I. PMID 2364091.
- Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990). „Activin B: precursor sequences, genomic structure and in vitro activities”. Mol. Endocrinol. 3 (9): 1352–8. DOI:10.1210/mend-3-9-1352. PMID 2575216.
- Feng ZM, Bardin CW, Chen CL (1989). „Characterization and regulation of testicular inhibin beta-subunit mRNA”. Mol. Endocrinol. 3 (6): 939–48. DOI:10.1210/mend-3-6-939. PMID 2739657.
- Barton DE, Yang-Feng TL, Mason AJ, et al. (1989). „Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice”. Genomics 5 (1): 91–9. DOI:10.1016/0888-7543(89)90091-8. PMID 2767687.
- Burger HG, Igarashi M (1988). „Inhibin: definition and nomenclature, including related substances”. Endocrinology 122 (4): 1701–2. DOI:10.1210/endo-122-4-1701. PMID 3345731.
- Mason AJ, Niall HD, Seeburg PH (1986). „Structure of two human ovarian inhibins”. Biochem. Biophys. Res. Commun. 135 (3): 957–64. DOI:10.1016/0006-291X(86)91021-1. PMID 3754442.
- Martens JW, de Winter JP, Timmerman MA, et al. (1997). „Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells”. Endocrinology 138 (7): 2928–36. DOI:10.1210/en.138.7.2928. PMID 9202237.
- Mellor SL, Cranfield M, Ries R, et al. (2001). „Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit”. J. Clin. Endocrinol. Metab. 85 (12): 4851–8. DOI:10.1210/jc.85.12.4851. PMID 11134153.
- Chapman SC, Woodruff TK (2001). „Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)”. Mol. Endocrinol. 15 (4): 668–79. DOI:10.1210/me.15.4.668. PMID 11266516.
- Salmenkivi K, Arola J, Voutilainen R, et al. (2001). „Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis”. J. Clin. Endocrinol. Metab. 86 (5): 2231–5. DOI:10.1210/jc.86.5.2231. PMID 11344232.
- Bahathiq AO, Stewart RL, Wells M, et al. (2002). „Production of activins by the human endosalpinx”. J. Clin. Endocrinol. Metab. 87 (11): 5283–9. DOI:10.1210/jc.2001-011884. PMID 12414903.