GABA transporter tip 1

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Familija trasportera rastvorka‎ 6 (neurotransmiterni transporter, GABA), član 1
Identifikatori
Simboli SLC6A1; GABATHG; GABATR; GAT1
Vanjski ID OMIM137165 MGI95627 HomoloGene2290 GeneCards: SLC6A1 Gene
Pregled RNK izražavanja
PBB GE SLC6A1 205152 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6529 232333
Ensembl ENSG00000157103 ENSMUSG00000030310
UniProt P30531 P31648
RefSeq (mRNA) NM_003042.3 NM_178703.4
RefSeq (protein) NP_003033.3 NP_848818.1
Lokacija (UCSC) Chr 3:
11.03 - 11.08 Mb
Chr 6:
114.28 - 114.32 Mb
PubMed pretraga [1] [2]

GABA transporter 1 (GAT-1, natrijum- i hlorid-zavisni GABA transporter 1) je protein koji je kod ljudi kodiran SLC6A1 genom.[1][2]

Funkcija[uredi - уреди]

GAT-1 je transporter gama-aminobuterne kiseline (GABA), koji uklanja GABA iz sinaptičkog rascepat.[3]

Interakcije[uredi - уреди]

SLC6A1 formira interakcije sa STX1A.[4][5][6]

Reference[uredi - уреди]

  1. Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). "Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25". Genomics 29 (1): 302–4. doi:10.1006/geno.1995.1253. PMID 8530094. 
  2. "Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6529. 
  3. Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). "Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity". Pharmacogenet. Genomics 19 (1): 53–65. doi:10.1097/FPC.0b013e328318b21a. PMID 19077666. 
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Literatura[uredi - уреди]

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