SCH-50911

Izvor: Wikipedia
SCH-50911
SCH-50911.svg
IUPAC ime
Identifikacija
CAS registarski broj 160415-07-6
PubChem[1][2] 5311429
ChemSpider[3] 4470917 YesY
MeSH SCH-50911
IUPHAR ligand 1075
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C8H15NO3
Molarna masa 173,21 g·mol−1
Tačka topljenja

154.5–157 °C (hidrohlorid)

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

SCH-50911 je selektivni antagonist GABAB[4]. On nalazi primenu u farmakološkim istraživanjima. Utvrđeno je da brzo i efektivno poništava simptome GHB predoziranja kod miševa. U jednom eksperimentu, miševima su date letalne doze GHB-a (7000 mg/kg) i tome su sledile promenljive doze SCH-50911. Na dve najviše doze antagonista (150 mg/kg i 300 mg/kg), samo 2 od 20 miševa je uginulo (10%), u poređenju sa 100% letalnošću kontrolne grupe.[5]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Blythin DJ, Kuo SC, Shue HJ, McPhail AT, Chapman RW, Kreutner W, Rizzo C, She HS, West R. Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and Related Compounds as Novel GABAB Antagonists. Bioorganic and Medicinal Chemistry Letters. 1996 Jul 9; 6(13): 1529-1534.
  5. Carai MA, Colombo G, Gessa GL. Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice. Annals of Emergency Medicine 2005 Jun;45(6):614-9.

Spoljašnje veze[uredi - уреди]