Protoporfirinogen oksidaza

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Protoporfirinogen oksidaza
Identifikatori
EC broj 1.3.3.4
CAS broj 53986-32-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Protoporfirinogen oksidaza (EC 1.3.3.4, protoporfirinogenska IX oksidaza, protoporfirinogenaza, PPO, Protox, HemG, HemY) je enzim sa sistematskim imenom protoporfirinogen-IX:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

protoporfirinogen IX + 3 O2 \rightleftharpoons protoporfirin IX + 3H2O2

Ovaj enzim je najmanje zastupljen u biosintezi hlorofila i hema. Postoje dva izoenzima kod biljki: jedan u plastidima i drugi u mitohondrijama. On je meta ftalimidnog i difenileterskog tipa herbicida.

Reference[uredi - уреди]

  1. Poulson, R. (1976). "The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX in mammalian mitochondria". J. Biol. Chem. 251: 3730–3733. PMID 6461. 
  2. Poulson, R. and Polglase, W.J. (1975). "The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX. Protoporphyrinogen oxidase activity in mitochondrial extracts of Saccharomyces cerevisiae". J. Biol. Chem. 250: 1269–1274. PMID 234450. 
  3. Dailey, H.A. and Dailey, T.A. (1996). "Protoporphyrinogen oxidase of Myxococcus xanthus. Expression, purification, and characterization of the cloned enzyme". J. Biol. Chem. 271: 8714–8718. PMID 8621504. 
  4. Wang, K.F., Dailey, T.A. and Dailey, H.A. (2001). "Expression and characterization of the terminal heme synthetic enzymes from the hyperthermophile Aquifex aeolicus". FEMS Microbiol. Lett. 202: 115–119. PMID 11506917. 
  5. Corrigall, A.V., Siziba, K.B., Maneli, M.H., Shephard, E.G., Ziman, M., Dailey, T.A., Dailey, H.A. (1998). ", Kirsch. R.E. and Meissner, P.N. Purification of and kinetic studies on a cloned protoporphyrinogen oxidase from the aerobic bacterium Bacillus subtilis". Arch. Biochem. Biophys. 358: 251–256. PMID 9784236. 
  6. Ferreira, G.C. and Dailey, H.A. (1988). "Mouse protoporphyrinogen oxidase. Kinetic parameters and demonstration of inhibition by bilirubin". Biochem. J. 250: 597–603. PMID 2451512. 
  7. Dailey, T.A. and Dailey, H.A. (1996). "Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme". Protein Sci. 5: 98–105. PMID 8771201. 
  8. Che, F.S., Watanabe, N., Iwano, M., Inokuchi, H., Takayama, S., Yoshida, S. and Isogai, A. (2000). "Molecular characterization and subcellular localization of protoporphyrinogen oxidase in spinach chloroplasts". Plant Physiol. 124: 59–70. PMID 10982422. 
  9. Dailey, T.A. and Dailey, H.A. (1998). "Identification of an FAD superfamily containing protoporphyrinogen oxidases, monoamine oxidases, and phytoene desaturase. Expression and characterization of phytoene desaturase of Myxococcus xanthus". J. Biol. Chem. 273: 13658–13662. PMID 9593705. 

Literatura[uredi - уреди]

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