UDP-N-acetilglukozamin kinaza
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| UDP-N-acetilglukozamin kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.176 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
UDP-N-acetilglukozamin kinaza (EC 2.7.1.176, UNAG kinaza, zeta toksin, toksin PezT, ATP:UDP-N-acetil-D-glukozaminska 3'-fosfotransferaza) je enzim sa sistematskim imenom ATP:UDP-N-acetil-alfa-D-glukozamin 3'-fosfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj protein je toksična komponenta toksin-antitoksin (TA) modula. Fosforilacija UDP-N-acetil-D-glukozamina dovodi do inhibicije EC 2.5.1.7, UDP-N-acetilglukozamin 1-karboksiviniltransferaze.
Reference[uredi | uredi kod]
- ↑ Khoo, S.K., Loll, B., Chan, W.T., Shoeman, R.L., Ngoo, L., Yeo, C.C. and Meinhart, A. (2007). „Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae”. J. Biol. Chem. 282: 19606-19618. PMID 17488720.
- ↑ Mutschler, H., Gebhardt, M., Shoeman, R.L. and Meinhart, A. (2011). „A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis”. PLoS Biol 9: #e1001033-e1001033. PMID 21445328.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.