A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza
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| A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.201 | ||||||||
| CAS broj | 119699-68-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza (EC 2.4.1.201, N-acetilglukozaminiltransferaza VI, N-glikozil-oligosaharid-glikoprotein N-acetilglukozaminiltransferaza VI, uridin difosfoacetilglukozamin-glikopeptid beta-1->4-acetilglukozaminiltransferaza VI, manozil-glikoprotein beta-1,4-N-acetilglukozaminiltransferaza, GnTVI) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:2,6-bis(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-glikoprotein 4-beta-N-acetil-D-glukozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-D-glukozamin + 2,6-bis(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-R UDP + 2,4,6-tris(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-R
R označava ostatak N-vezanog oligosaharida u glikoproteinskom akceptoru.
Reference[uredi | uredi kod]
- ↑ Brockhausen, I., Hull, E., Hindsgaul, O., Schachter, H., Shah, R.N., Michnick, S.W. and Carver, J.P. (1989). „Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc β1-6 (GlcNAc β1-2)Man α-R (GlcNAc to Man) β-4-N-acetylglucosaminyltransferase VI”. J. Biol. Chem. 264: 11211-11221. PMID 2525556.
- ↑ Taguchi, T., Ogawa, T., Inoue, S., Inoue, Y., Sakamoto, Y., Korekane, H. and Taniguchi, N. (2000). „Purification and characterization of UDP-GlcNAc:GlcNAcβ1-6(GlcNAcβ1-2)Manα1-R [GlcNAc to Man]-β1,4-N-acetylglucosaminyltransferase VI from hen oviduct”. J. Biol. Chem. 275: 32598-32602. PMID 10903319.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.