Trans-2,3-dihidro-3-hidroksiantranilatna izomeraza
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| Trans-2,3-dihidro-3-hidroksiantranilatna izomeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.3.3.17 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Trans-2,3-dihidro-3-hidroksiantranilatna izomeraza (EC 5.3.3.17, phzF (gen)) je enzim sa sistematskim imenom (5S,6S)-6-amino-5-hidroksicikloheksan-1,3-dien-1-karboksiat izomeraza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5S,6S)-6-amino-5-hidroksicikloheksan-1,3-dien-1-karboksiat (1R,6S)-6-amino-5-oksocikloheks-2-en-1-karboksilat
Ovaj enzim učestvuje u fenazinskoj biosintezi.
Reference[uredi | uredi kod]
- ↑ Parsons, J.F., Song, F., Parsons, L., Calabrese, K., Eisenstein, E. and Ladner, J.E. (2004). „Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79”. Biochemistry 43: 12427-12435. PMID 15449932.
- ↑ Blankenfeldt, W., Kuzin, A.P., Skarina, T., Korniyenko, Y., Tong, L., Bayer, P., Janning, P., Thomashow, L.S. and Mavrodi, D.V. (2004). „Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens”. Proc. Natl. Acad. Sci. USA 101: 16431-16436. PMID 15545603.
- ↑ Parsons, J.F., Calabrese, K., Eisenstein, E. and Ladner, J.E. (2004). „Structure of the phenazine biosynthesis enzyme PhzG”. Acta Crystallogr. D Biol. Crystallogr. 60: 2110-2113. PMID 15502343.
- ↑ Mavrodi, D.V., Bleimling, N., Thomashow, L.S. and Blankenfeldt, W. (2004). „The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79”. Acta Crystallogr. D Biol. Crystallogr. 60: 184-186. PMID 14684924.
- ↑ Ahuja, E.G., Janning, P., Mentel, M., Graebsch, A., Breinbauer, R., Hiller, W., Costisella, B., Thomashow, L.S., Mavrodi, D.V. and Blankenfeldt, W. (2008). „PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis”. J. Am. Chem. Soc. 130: 17053-17061. PMID 19053436.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.