Timetna oligopeptidaza
(Preusmjereno sa stranice Timet oligopeptidaza)
| Timetna oligopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.15 | ||||||||
| CAS broj | 110639-28-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Timetna oligopeptidaza (EC 3.4.24.15, Pz-peptidaza, rastvorna metaloendopeptidaza, endo-oligopeptidaza A, tkivna endopeptidaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Preferentno razlaganje veza sa hidrofobnim ostatacima na P1, P2 i P3', kao i malih ostataka u P1' u supstratima sa 5-15 ostataka
Ovo tiolno jedinjenje se aktivira pri niskim koncentracijama.
Reference[uredi | uredi kod]
- ↑ Cicilini, M.A., Ribeiro, M.J.F., de Oliveira, E.B., Mortara, R.A. and de Camargo, A.C.M. (1988). „Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides”. Peptides (Fayetteville) 9: 945-955. PMID 3244563.
- ↑ Orlowski, M., Reznik, S., Ayala, J. and Pierotti, A.R. (1989). „Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides”. Biochem. J. 261: 951-958. PMID 2803255.
- ↑ Barrett, A.J. and Brown, M.A. (1990). „Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase”. Biochem. J. 271: 701-706. PMID 2123097.
- ↑ Pierotti, A., Dong, K.W., Glucksman, M.J., Orlowski, M. and Roberts, J.L. (1990). „Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15”. Biochemistry 29: 10323-10329. PMID 2261476.
- ↑ Tisljar, U. and Barrett, A.J. (1990). „Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit”. Biochem. J. 267: 531-533. PMID 2185743.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.