Propionat kinaza
(Preusmjereno sa stranice TdcD)
| Propionat kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.2.15 | ||||||||
| CAS broj | 39369-28-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Propionat kinaza (EC 2.7.2.15, PduW, TdcD, propionat/acetatna kinaza) je enzim sa sistematskim imenom ATP:propanoat fosfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
Za dejstvo ovog enzima je neophodan jon Mg2+.
Reference[uredi | uredi kod]
- ↑ Heßlinger, C., Fairhurst, S.A. and Sawers, G. (1998). „Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate”. Mol. Microbiol. 27: 477-492. PMID 9484901.
- ↑ Palacios, S., Starai, V.J. and Escalante-Semerena, J.C. (2003). „Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol”. J. Bacteriol. 185: 2802-2810. PMID 12700259.
- ↑ Wei, Y. and Miller, C.G. (1999). „Characterization of a group of anaerobically induced, fnr-dependent genes of Salmonella typhimurium”. J. Bacteriol. 181: 6092-6097. PMID 10498722.
- ↑ Ingram-Smith, C., Gorrell, A., Lawrence, S.H., Iyer, P., Smith, K. and Ferry, J.G. (2005). „Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase”. J. Bacteriol. 187: 2386-2394. PMID 15774882.
- ↑ Simanshu, D.K. (2005). „Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium”. Acta Crystallogr. F Struct. Biol. Cryst. Commun. 61: 52-55. PMID 16508089.
- ↑ Simanshu, D.K., Savithri, H.S. and Murthy, M.R. (2005). „Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily”. J. Mol. Biol. 352: 876-892. PMID 16139298.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.