TRNK (guanin9-N1)-metiltransferaza
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| tRNK (guanin9-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.221 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
tRNK (guanin9-N1)-metiltransferaza (EC 2.1.1.221, Trm10p, tRNK(m1G9/m1A9)-metiltransferaza, tRNK(m1G9/m1A9)MTaza, tRNK (guanin-N(1)-)-metiltransferaza, tRNK m1G9-metiltransferaza, tRNK m1G9 MTaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin9-N1)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanin9 u tRNK S-adenozil-L-homocistein + N1-metilguanin9 u tRNK
Enzim iz Saccharomyces cerevisiae specifično metiluje guanin9. Bifunkcionalani enzim iz Thermococcus kodakaraensis takođe katalizuje metilaciju adenina9 u tRNK (cf. EC 2.1.1.218, tRNK (adenin9-N1)-metiltransferaza).
Reference[uredi | uredi kod]
- ↑ Kempenaers, M., Roovers, M., Oudjama, Y., Tkaczuk, K.L., Bujnicki, J.M. and Droogmans, L. (2010). „New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA”. Nucleic Acids Res. 38: 6533-6543. PMID 20525789.
- ↑ Jackman, J.E., Montange, R.K., Malik, H.S. and Phizicky, E.M. (2003). „Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9”. RNA 9: 574-585. PMID 12702816.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.