TRNK (guanin26-N2)-dimetiltransferaza
Prijeđi na navigaciju
Prijeđi na pretragu
| TRNK (guanin26-N2)-dimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.216 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK (guanin26-N2)-dimetiltransferaza (EC 2.1.1.216, Trm1p, TRM1, tRNK (m22G26)dimetiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin26-N2)-dimetiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 S-adenozil-L-metionin + guanin26 u tRNK 2 S-adenozil-L-homocistein + N2-dimetilguanin26 u tRNK
Enzim se disocira od svog tRNK supstrata između dve konsekutivne reakcije metilacije. Za razliku od EC 2.1.1.215, tRNK (guanin26-N2/guanin27-N2)-dimetiltransferaze, ovaj enzim ne katalizuje metilaciju guanina27 u tRNK.
Reference[uredi | uredi kod]
- ↑ Constantinesco, F., Motorin, Y. and Grosjean, H. (1999). „Characterisation and enzymatic properties of tRNA(guanine26, N2,N2-dimethyltransferase (Trm1p) from Pyrococcus furiosus”. J. Mol. Biol. 291: 375-392. PMID 10438627.
- ↑ Constantinesco, F., Benachenhou, N., Motorin, Y. and Grosjean, H. (1998). „The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli”. Nucleic Acids Res. 26: 3753-3761. PMID 9685492.
- ↑ Liu, J., Liu, J. and Straby, K.B. (1998). „Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase”. Nucleic Acids Res. 26: 5102-5108. PMID 9801306.
- ↑ Liu, J., Zhou, G.Q. and Straby, K.B. (1999). „Caenorhabditis elegans ZC376.5 encodes a tRNA (m22G26)dimethyltransferance in which 246arginine is important for the enzyme activity”. Gene 226: 73-81. PMID 10048958.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.